Action and indications for use:
GRYPOLEK® is a compound medication consisting of four active substances, used in general conditions of cold, headache and muscle pain, fever, sore throat, nasal congestion, and cough caused by cold. Paracetamol exhibits antipyretic and analgesic effects. Pseudoephedrine hydrochloride constricts blood vessels, thereby clearing the nose and sinuses, facilitating unrestricted breathing. Dextromethorphan hydrobromide acts effectively as an antitussive, especially in cases of dry, irritating cough. Guaifenesin is an expectorant that stimulates the bronchial mucosa to produce mucus. It causes thinning and liquefaction of secretions, making them easier to expectorate.
Contraindications:
Hypersensitivity to active substances or any excipient. Children under 6 years of age. Hypertension, heart disease, diabetes, hyperthyroidism, difficulty urinating associated with prostate disease, severe kidney and liver failure, anemia. Concurrent use with other medicines containing paracetamol. Use of Parkinson's disease medications, antidepressants, monoamine oxidase inhibitors, and within two weeks after discontinuation of monoamine oxidase inhibitors.
Interactions with other drugs and other types of interactions:
Drugs that accelerate gastric emptying, e.g., metoclopramide, accelerate the absorption of paracetamol, while drugs that delay its emptying, e.g., propantheline, as well as cholestyramine and all anticholinergics, may delay its absorption. Paracetamol used together with rifampicin, antiepileptic drugs, barbiturates increases the risk of liver damage, whereas with zidovudine, it may intensify the toxic effects of this substance on the bone marrow. Paracetamol prolongs the half-life of chloramphenicol and increases its toxicity, it may also intensify the action of anticoagulant drugs (coumarins). Observations of interactions between sympathomimetics (ephedrine, noradrenaline) and centrally acting antihypertensive drugs (guanethidine, methyldopa) indicate that the use of pseudoephedrine may increase blood pressure and cause heart rhythm disturbances. Drugs inhibiting the functioning of cytochrome CYP2D6, e.g., fluoxetine, haloperidol, quinidine, venlafaxine, may inhibit the metabolism of dextromethorphan. Concurrent use of drugs containing pseudoephedrine and certain dietary supplements containing ephedrine derivatives increases the risk of adverse effects. Due to the high probability of interactions, do not use with monoamine oxidase inhibitors (MAO) or within two weeks after discontinuation of treatment, as well as with serotonin reuptake inhibitors.
Pregnancy and breastfeeding:
GRYPOLEK® should not be used in pregnant women or during breastfeeding.
Driving and operating machinery:
During the use of GRYPOLEK® caution should be exercised while driving and operating machinery, due to the possibility of adverse effects on the central nervous system, e.g., drowsiness, hallucinations.
Adverse reactions:
Like any medicine, this medicine may cause adverse reactions, although not everyone experiences them. The active substances contained in GRYPOLEK® rarely cause the following adverse reactions: nausea, vomiting, heartburn, liver dysfunction, heart rhythm disturbances, changes in blood pressure, and changes in blood morphology, including: anemia (a set of symptoms caused by iron deficiency), methemoglobinemia (a condition in which hemoglobin contains trivalent instead of divalent iron ions, losing the ability to transport oxygen), agranulocytosis (a disease caused by a significant decrease in the number of granulocytes, one of the types of white blood cells), dizziness, visual, sensory, and taste disturbances, drowsiness, anxiety, nervousness, hallucinations, psychomotor agitation. The medicine may cause asthma attacks and skin changes. Other adverse reactions include renal dysfunction, urinary tract stones (a disease associated with the formation of stones in the kidneys), and urinary retention. If any adverse reactions occur, including any possible adverse reactions not listed above, consult a doctor or pharmacist.
Overdose:
Do not exceed the recommended doses, due to the high probability of adverse effects, which may manifest as gastrointestinal disorders: nausea, vomiting, abdominal pain, jaundice, diarrhea, and neurological disorders: psychiatric disturbances, drowsiness, as well as cardiovascular disorders, including heart rhythm disturbances, increased blood pressure. In case of the above symptoms, contact a doctor immediately. Do not use this medicine after the expiration date stated on the box.
