When not to use Tribiotic®:
- if the patient is allergic to neomycin sulfate, polymyxin B sulfate, zinc bacitracin, or any other ingredients of this medicine (listed in section 6);
- in children under 12 years of age (see section: "Children and Adolescents");
- on mucous membranes; in the eyes;
- on a large area of damaged skin;
- on deep wounds or punctures;
- on severe burns; on oozing skin lesions.
Warnings and precautions:
Before starting to use Tribiotic®, discuss it with a doctor or pharmacist. If there is no improvement, if symptoms worsen, or if signs of hypersensitivity occur, including skin reactions such as rash, itching, irritation, and severe allergic reactions, discontinue use of Tribiotic® and consult a doctor. If a severe allergic reaction occurs, immediately stop using Tribiotic® and seek medical attention. If the patient is allergic to any antibiotic from the aminoglycoside or polymyxin group, they may also be allergic to this medicine. Do not use the medication on large areas of damaged skin because its active ingredients, when absorbed into the bloodstream, can cause hearing loss, kidney damage, and neurotoxic effects. Use Tribiotic® with caution in patients with kidney disease and/or hearing impairment due to the risk of toxic effects on the kidneys and hearing. Concurrent use of Tribiotic® with other medications harmful to the kidneys and hearing may enhance the effects of these drugs (see section: "Tribiotic® and other drugs").
Children and adolescents:
Do not use the medication in children under 12 years of age due to the risk of toxic effects on hearing and kidneys.
Tribiotic® and other drugs:
Inform the doctor or pharmacist about all medications currently or recently taken by the patient, as well as any medications the patient plans to take. After applying Tribiotic® ointment to a large skin area or damaged skin, interactions with other concurrently used medications may occur. In particular, inform the doctor: if the patient is taking neomycin orally (an antibiotic), as concurrent use with Tribiotic® may increase the risk of allergic reactions; if the patient is using medications that may damage the kidneys and organs of hearing, such as potent diuretics like ethacrynic acid. These medications, when used concurrently with aminoglycoside antibiotics, increase their blood concentration, enhancing the risk of hearing impairment, up to deafness, which may occur even after discontinuation of this medication; if the patient is concurrently taking orally or using topically aminoglycoside antibiotics or other drugs with possible harmful effects on the kidneys or nervous system, as adverse effects may be intensified.
Pregnancy and breastfeeding:
If the patient is pregnant, breastfeeding, suspects she may be pregnant, or is planning to have a baby, she should consult a doctor or pharmacist before using this medication. Due to the lack of adequate studies, the medication should not be used during pregnancy and in breastfeeding women.
Driving and using machines:
The effect of Tribiotic® on driving and operating machinery is unknown.
